Sometimes in the middle of a risky venture, I am at my worst mentally and emotionally. One study I read described entrepreneurs as one of the most mentally unstable people. Its like riding a killer whale; Onlookers commend for your confidence for taking the risk but in truth, the entrepreneur is terrified to death, wondering how on earth he got there in the first place.
Just a word of advise, getting back in the game may prove to be a lot harder than you may anticipate. So think long and hard before you make the decision to take a long period off because there might not be a job or work to come back to when the break is over. In my situation it worked well because I was changing direction in my career all together,so the break proved more helpful because I got the time to re-educate myself and create a new network of people I needed in order to accomplish my company's goals.
Your twenties is the best time to take a few risks and if this means taking time off to rethink your life's plan, you owe it yourself to search the depth of your soul to find out what makes you tick, what gets you out of your bed each morning and everything else in between.